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首頁(yè) /藥靶模型 /激酶靶點(diǎn) /c-Kit /c-Kit L576P/BaF3

c-Kit L576P/BaF3

CBP73298

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I. Background

KIT L576P lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 17372901). L576P confers a gain of function to Kit, as indicated by constitutive phosphorylation of Kit, and is transforming in cell culture (PMID: 17372901).

 
II. Introduction

Cell Line Name:

c-Kit L576P/BaF3

Host Cell:

Ba/F3

Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

 
III. Representative Data

1. WB of c-Kit L576P/BaF3

 

2. Sanger of c-Kit L576P/BaF3

3. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BaF3 c-KIT L576P (C6).


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